Salusin-ß (Human) (0.1mg vial)

Product overview
Catalog Number
PPH08-0945
Sequence
Ala-Ile-Phe-Ile-Phe-Ile-Arg-Trp-Leu-Leu-Lys-Leu-Gly-His-His-Gly-Arg-Ala-Pro-Pro
Target
Hypotensive / Mitogenic Peptide
Description
The polypeptide Salusin-beta shows hypotensive effects and stimulates proliferation and bradycardia in vascular smooth muscle cells. Salusin-beta is suspected to be a new regulatory factor for myocardial growth and hypertrophy. Salusin-β increased mRNA expression and protein level of IL-6, IL-8 and IL-18. This protein decreased mRNA and protein level of IL-1Ra in HUVECs. NF-ƙβ signaling pathway was involved in the up-regulatory effect of salusin-β on mRNA expression of pro-inflammatory cytokines. The down-regulatory effect of salusin- β on IL-1Ra expression could not be influenced by Bay 11-7082 pre-treatment. It seems that salusin-β may participate in a cascade pathway in vascular inflammation. that salusin-β has potential use as a therapeutic target for atherosclerosis. (M.W. 2342.8) C115H176N32O21. Synthetic Product. Hypotensive / Mitogenic Peptide
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
Price

€109,00
  • For research use only
  • Not for use in diagnostic procedures

€109,00 Tax excluded
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