Tertiapin Q

Product overview

Sequence: H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2

Target: Tertiapin analog; Exhibits similar blocking activity as bee venom peptide tertiapin for Inward-Rectifier K+ Channel but has the advantage of increased stability due to replacement of Met by Gln, Occurs in honeybee venom

Description: Tertiapin-Q is an oxidation-resistant mutant of the wild-type tertiapin where Methionine 13 has been replaced by a Glutamine. Tertiapin-Q blocks the inwardly rectifying Kir1.1 (ROMK1) and Kir3.1/3.4 (GIRK1/GIRK4 also known as IKACh) potassium channels with Kd values of around 2 nM and 8 nM respectively.Tertiapin-Q also inhibits calcium-activated large conductance BK potassium channels (KCa1.1) in a concentration and voltage-dependent manner (IC50 ~ 5 nM), in addition to inhibiting Kir3.1/3.2 (GIRK1/GIRK2) heteromultimer potassium channels with a Kd close to 270 nM. Tertiapin-Q can prevent dose-dependent acetylcholine(Ach)-induced atrioventricular blocks in mammalian hearts, as KCNJ3/KCNJ5 channels (also named I(KACh)), are activated by Ach found in mammalian myocytes. Tertiapin analog; Exhibits similar blocking activity as bee venom peptide tertiapin for Inward-Rectifier K+ Channel but has the advantage of increased stability due to replacement of Met by Gln. Host: Bee Venom. Trifluoroacetate Salt. C106H175N35O24S4. CAS: 252198-49-5. Disulfide Bonds: Cys3-Cys14, Cys5-Cys18

Quantity	1mg, 5mg
Storage	Shipped at 4°C. Store at -20°C for one year.
Purity	> 95%
Source	Synthetic
Forma appearance	Lyophilized powder

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