Lentil Bean BBI

Product overview
Catalog Number
PPH07-237
Sequence
GDDVKSACCDTCLCTRSQPPTCRCVDVRESCHSACDKCV CAYSNPPQCQCYDTHKFCYKACHNSEIEE
Target
Disease Prevention and Therapy
Description
BBI from lentil bean is a monomer comprised of 68 amino acids and forms a 1:1 stoichiometric complex with the protease active site. The complex of the inhibitor with either trypsin or chymotrypsin has no further inhibitory effect toward more of the same enzyme, but has full activity towards the other enzyme (forming 1:1:1 complex). This implies that there is one binding site for trypsin and another for chymotrypsin. Trypsin binds to a Lys-Ser site, while chymotrypsin binds to a Leu-Ser site. Inhibition is both reversible and pH dependent. Dissociation of this complex may yield a modified or native form of the inhibitor. The optimal pH for trypsin binding is 8.0 with an association constant of greater than 109 at pH 8.0, and an association constant of 0.15-2.6 x 104 at pH 3.6-4.4.
Category
Enzyme Inhibitors and Substrates, Catalog peptides
Product Properties
Quantity

50µg, 100µg, 500µg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€350,00 – €2.000,00 Tax excluded
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