E-64-d (5 mg vial)
Product overview
- Catalog Number
- PPH08-0430
- Sequence
- (L-3-trans-Ethoxycarbonyloxirane-2-Carbonyl)-L-Leucine (3-Methylbutyl)Amide
- Target
- Inhibitor for Thiol Protease (Cathepsin B/H/Land Calpain) Membrane Permeable Analog of E-64-c; Calpain inhibitor
- Description
- E-64-d is a derivative of the membrane permeant E-64c (sc-201278) and acts as a potent inhibitor of thiol protease. E-64-d can permeate an intact cell and block the activity of calpain, which results in the protection of protein kinase C (PKC) from proteolysis. E-64-d is also a cathepsin B, cathepsin H, and cathepsin L inhibitor. Research shows that E-64-d can enhance compromised natural killer cells and bactericidal activity of leukocytes. In addition, E-64-d has been shown to induce cell cycle arrest during prophase and metaphase in Xenopus embryonic cells. E-64-d inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A. E-64-d is also known as EST, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester, Loxistatin, E-64d, Aloxistatin, E-64c ethyl ester, EP 453, NSC 694281, and 3-[[[(1S)-3-methyl-1[[(3S-methylbutyl) amino] carbonyl] butyl] amino] carbonyl]-2S-oxiranecarboxylic acid, ethyl ester. (L-3-trans-Ethoxycarbonyloxirane-2-Carbonyl)-L-Leucine (3-Methylbutyl)Amide (M.W. 342.43) C17H30N2O5 [88321-09-9] Synthetic Product Inhibitor for Thiol Protease (Cathepsin B/H/Land Calpain) Membrane Permeable Analog of E-64-c
Category
Product Properties
| Quantity | 1mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €104,00 |
- For research use only
- Not for use in diagnostic procedures
€104,00 Tax excluded
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