H-Ala-Tyr-Pro-Gly-Lys-Phe-NH₂

Product overview
Catalog Number
PPH08-0512
Sequence
H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2
Target
Selective Protease-Activated Receptor 4 (PAR4) Agonist
Description
Proteinase-Activated Receptor 4 Activating Peptide. (Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively).1,2 It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets.2 (Ala1)-PAR4 (1-6) amide (mouse) induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips (EC50s = 11 and 110 μM, respectively) as well as inhibits calcium mobilization evoked by capsaicin (Item No. 92350) in rat sensory neurons.3,4 In vivo, (Ala1)-PAR4 (1-6) amide (mouse) (1-100 µg) increases latency to paw withdrawal and the nociceptive threshold in response to thermal and mechanical stimuli.4 (Ala1)-PAR4 (1-6) amide (mouse) (200 µg) also increases paw thickness in a rat paw edema assay.AYPGKF-Amide (M.W. 680.81) C34H48N8O7 Selective Protease-Activated Receptor 4 (PAR4) Agonist. L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide, trifluoroacetate salt
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg, 5mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€29,00 – €172,00 Tax excluded
Contact us to request price here
Register to buy peptides
Contact us