H-Ser-Phe-Asn-Gly-Gly-Pro-NH₂

Product overview
Catalog Number
PPH08-0534
Sequence
H-Ser-Phe-Asn-Gly-Gly-Pro-NH2
Target
PAR3 Tethered Ligand (Murine) / Activates PAR1 and PAR2
Description
L-seryl-L-phenylalanyl-L-asparaginylglycylglycyl-L-prolinamide, trifluoroacetate salt. PAR3 (1-6) amide is a synthetic hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse proteinase-activated receptor 3 (PAR3) and residues 38-43 of the full-length sequence. PAR3 (1-6) amide activates PAR1 and PAR2, but not PAR3 or PAR4.1,2 It does not induce thrombin signaling in COS-7 cells expressing PAR3, PAR4, or both receptors at concentrations less than or equal to 500 µM, however, it does activate PAR1 and PAR2 in a cross-desensitization assay in Jurkat T cells when used at concentrations of 500 and 1,000 µM.1,2 PAR3 (1-6) increases calcium levels in Kirsten virus-transformed rat kidney (KNRK) cells expressing rat or human PAR2, with a higher potency for rat PAR2.
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg, 5mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€29,00 – €172,00 Tax excluded
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