Mastoparan (0.5 mg vial)
Product overview
- Catalog Number
- PPH08-0709
- Sequence
- Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
- Target
- A cell-penetrating peptide toxin whose sequence is derived from wasp venom and a potent activator of heterotrimeric G proteins
- Description
- Peptide to Mastoparan. Mastoparan is a mast cell degranulating peptide originally isolated from Vespid wasp venom.1 It promotes degranulation by increasing GTPase activity for Gi and Go signaling independent of G protein-coupled receptor binding.2,3 Mastoparan also binds calmodulin (Kd = 0.3 nM) and inhibits the calmodulin-induced activation of phosphodiesterase (IC50 = 0.02 µM).4,5 In vitro, mastoparan was effective in killing leukemia, myeloma, and breast cancer cells (IC50s = 8-9.2, 11, and 20-24 µM, respectively).6 It worked synergistically with gemcitabine in a mouse model of mammary carcinoma.6
Category
Product Properties
| Quantity | 1mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €61,00 |
- For research use only
- Not for use in diagnostic procedures
€61,00 Tax excluded
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