Midkine (Human) (50 μg vial)
Product overview
- Catalog Number
- PPH08-0716
- Sequence
- Lys-Lys-Lys-Asp-Lys-Val-Lys-Lys-Gly-Gly-Pro-Gly-Ser-Glu-Cys-Ala-Glu-Trp-Ala-Trp-Gly-Pro-Cys-Thr-Pro-Ser-Ser-Lys-Asp-Cys-Gly-Val-Gly-Phe-Arg-Glu-Gly-Thr-Cys-Gly-Ala-Gln-Thr-Gln-Arg-Ile-Arg-Cys-Arg-Val-Pro-Cys-Asn-Trp-Lys-Lys-Glu-Phe-Gly-Ala-Asp-Cys-Lys-Lys
- Target
- Heparin-Binding Growth/Differentiation Factor (Neurotrophic Factor, Neurite Outgrowth-Promoting Factor) Plasminogen Activator Activity Enhancer
- Description
- Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis. Midkine (MK) also known as neurite growth-promoting factor 2 (NEGF2) is a protein that in humans is encoded by the MDK gene. MK is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. It is pleiotropic, capable of exerting activities such as cell proliferation, cell migration, angiogenesis and fibrinolysis. MK may potentially be indirectly targeted as a cancer treatment as a result of its cancerous proliferation properties. Besides, Low Density Lipoprotein Receptor Related Protein 1 (LRP1) has been identified as an interactor of MK, thus a binding ELISA assay was conducted to detect the interaction of recombinant human MK and recombinant human LRP1. Briefly, MK were diluted serially in PBS, with 0.01% BSA (pH 7.4).
Category
Product Properties
| Quantity | 1mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €408,00 |
- For research use only
- Not for use in diagnostic procedures
€408,00 Tax excluded
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