ProTx-I (0.1mg vial)
Product overview
- Catalog Number
- PPH08-0890
- Sequence
- Glu-Cys-Arg-Tyr-Trp-Leu-Gly-Gly-Cys-Ser-Ala-Gly-Gln-Thr-Cys-Cys-Lys-His-Leu-Val-Cys-Ser-Arg-Arg-His-Gly-Trp-Cys-Val-Trp-Asp-Gly-Thr-Phe-Ser
- Target
- Synthetic Product T-Type Ca2+ Channel / Na+ Channel / K+ Ion Channel Blocker (Gating Modifier), spider venom-peptide whose sequence is derived from the Tarantula, Thrixopelma pruriens.
- Description
- Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8(IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2 (Tarantula, Thrixopelma pruriens) (Disulfide bonds between Cys2-Cys16, Cys9-Cys21, and Cys15- Cys28) (M.W. 3987.50) C171H245N53O47S6 Synthetic Product T-Type Ca2+ Channel / Na+ Channel / K+ Channel Blocker (Gating Modifier)
Category
Product Properties
| Quantity | 1mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €280,00 |
- For research use only
- Not for use in diagnostic procedures
€280,00 Tax excluded
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