We are seeking a highly motivated Peptide Chemist to:

• Perform synthesis process including solution phase and solid phase peptide synthesis, peptide resin cleavage, resin cleavage with HF or other chemical cocktails
• Perform purification process by chromatography, crystallization and other techniques, and in-process test method.
• Experience in handling automated peptide synthesizer and skills in peptide purification/characterization techniques would be preferred. 
• Participate in peptide design/discovery and data-driven (structure activity relationship based) lead optimization.
• Prepare (using automated solid-phase peptide synthesizer), purify, and characterize peptides
• Maintain the team’s peptide synthesizers
• Follow approved GMP manufacture directions such as Master Batch Records, Standard Operation Procedures, Standard Test Procedures and other procedures to manufacture GMP materials, perform in-process test, package the product including other related activities
• Perform project-planning and initiate raw material order-request. Receive raw materials, coordinate with Quality Analysis (QA)/Quality Control (QC) and Material Management for material release and monitor raw material inventories.
• Install, test equipment, operate and maintain equipment for manufacturing and in-process testing. The equipment includes analytical HPLC and prep HPLC system, Lyophilizes, balances, reactors, diafiltration systems, water purification systems, oven, washing systems and others used in manufacture
• Follow and maintain GMP Documentation System. Investigate any process deviation and write process deviation report. Initiate document change request. Help quality control and assurance unit to maintain equipment calibration program
• Routinely maintain/organize work areas (Hood, bench, floor, wall, etc.) and other designated areas at the manufacturing facility
• Develop peptide-manufacturing processes including peptide/protein purification by chromatography, crystallization, and other techniques, and in process test methods
• Assist QA/QC for monitoring raw material inventories
• Write Standard Operation Procedures, Standard Test Procedures, Master Batch Records and other related GMP documents
• Follow SOPs and approved directions to clean equipment used in GMP processes, maintain cleaning log for each equipment, assist in equipment calibration program, and dispose chemical waste generated in the manufacture
• Monitor compliance of Maintenance and Cleaning procedures of equipment and instruments used in GMP processes by periodically reviewing and signing off on maintenance and cleaning log for each equipment.
• Prepare Quality Control samples for HPLC and Maldi-TOF analysis. Operates the HPLC and Maldi-TOF, acquires high quality data from the instruments.
• Coordinate with a variety of groups to quote, manufacture, package and ship for sale custom ordered peptides.
• Inventory all raw materials and promptly places orders as necessary. Communicates supply issues to lab members.
• Maintain and troubleshoot all lab equipment and instrumentation.
• Respond to peptidyl inquires directed to the Peptide Lab in a timely, informative and professional manner.