Actinonin

Product overview
Catalog Number
PPH08-0076
Sequence
3-[[1-[[2-(Hydroxymethyl)-1-Pyrolidinyl]-Carbonyl]- 2-Methylpropyl]-Carbamoyl]-Octanohydroxamic Acid
Target
Inhibitor for Aminopeptidase M and Leucyl Aminopeptidase, Inhibits Bacterial Growth by Targeting Peptide Deformylase (PDF). Inhibits Aminopeptidase N (APN, or CD13) and has Antitumor Activity.
Description
Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM). Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins. Actinonin has also been identified as an effective inhibitor of human meprin α (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins. More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

25mg, 100mg, 1000mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€346,00 – €8.540,00 Tax excluded
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