Adjuvant Peptide

Product overview
Catalog Number
PPH08-0020
Sequence
N-Ac-Muramyl-Ala-D-Glu-NH2 • 2H2O
Target
The capacity of five different adjuvants, AlPO4, a muramyldipeptide formulation (MDP.TSL), Freund's adjuvant, immunostimulating complex and its matrix components to elicit humoral and cellular responses in rabbits immunized with the human immunodeficiency
Description
Fragments of the bacterial cell wall peptidoglycan, murein, have long been known to have potent adjuvant properties. The synthetic versions of these molecules and murein-component derivatives are known as adjuvant peptides. The murein component N-acetylmuramylalanyl-d-isoglutamine (MDP) has been shown to functionally substitute for killed mycobacteria in Freund’s Complete Adjuvant, and the repeating unit of murein, N-acetylglucosaminyl-1,4-N-acetylmuramylalanyl-d-isoglutamine (glucosaminylmuramyl dipeptide, GMDP) has an even stronger immunomodulatory activity than MDP. Synthetic versions of these molecules and other murein-component derivatives have been extensively studied as potential adjuvants for human use, but significant side effects such as pyrogenicity and uveitis have prevented their acceptance for clinical use. The peptides were isolated by using a GMDP-specific antibody to screen a phage-display library, selecting for peptides that mimic the biochemical properties and/or the biophysical shape of the GMDP molecule. 4. Sequence of muramyl adjuvant peptide is Ac-muramyl-D-Ala-D-Glu-NH2.
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

25mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
Price

€890.00
  • For research use only
  • Not for use in diagnostic procedures

€890,00 Tax excluded
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