Adjuvant Peptide (0.5 mg vial)
Product overview
- Catalog Number
- PPH08-0021
- Sequence
- N-Ac-Muramyl-Ala-D-Glu-NH2
- Target
- The capacity of five different adjuvants, AlPO4, a muramyldipeptide formulation (MDP.TSL), Freund's adjuvant, immunostimulating complex and its matrix components to elicit humoral and cellular responses in rabbits immunized with the human immunodeficiency
- Description
- Fragments of the bacterial cell wall peptidoglycan, murein, have long been known to have potent adjuvant properties. The synthetic versions of these molecules and murein-component derivatives are known as adjuvant peptides. The murein component N-acetylmuramylalanyl-d-isoglutamine (MDP) has been shown to functionally substitute for killed mycobacteria in Freund’s Complete Adjuvant, and the repeating unit of murein, N-acetylglucosaminyl-1,4-N-acetylmuramylalanyl-d-isoglutamine (glucosaminylmuramyl dipeptide, GMDP) has an even stronger immunomodulatory activity than MDP. Synthetic versions of these molecules and other murein-component derivatives have been extensively studied as potential adjuvants for human use, but significant side effects such as pyrogenicity and uveitis have prevented their acceptance for clinical use. The peptides were isolated by using a GMDP-specific antibody to screen a phage-display library, selecting for peptides that mimic the biochemical properties and/or the biophysical shape of the GMDP molecule. 4. Sequence of muramyl adjuvant peptide is Ac-muramyl-D-Ala-D-Glu-NH2.
Category
Product Properties
| Quantity | 1mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €29,00 |