Anti Nociceptin / Orphanin FQ (Human, Rat) Serum (50 ul)
Product overview
- Catalog Number
- PPH08-0093
- Sequence
- Phe - Gly - Gly - Phe - Thr - Gly - Ala - Arg - Lys - Ser - Ala - Arg - Lys - Leu - Ala - Asn - Gln
- Target
- Neuromodulation of anxiety, stress and hypothalamic-pituitary-adrenal (HPA) axis activity.
- Description
- Nociceptin/orphanin FQ (N/OFQ) peptide and its receptor (NOP) function in the neuromodulation of anxiety, stress and hypothalamic-pituitary-adrenal (HPA) axis activity. We investigated the endogenous NOP system using the selective NOP antagonist, UFP-101, during the HPA axis response to bacterial endotoxin, lipopolysaccharide (LPS). Although i.c.v. N/OFQ (1 μg/rat) had no significant effect on LPS-induced (250 μg/rat i.p) plasma corticosterone release at 30 or 60 min post-i.c.v. injection, i.c.v. UFP-101 (1 μg/rat)/LPS significantly attenuated plasma adrenocorticotrophic hormone and corticosterone at the 30-min time-point compared to i.c.v saline (0.9%)/LPS.
Category
Product Properties
| Quantity | 1mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €408,00 |
- For research use only
- Not for use in diagnostic procedures
€408,00 Tax excluded
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