Antide Acetate

Product overview
Catalog Number
PPH08-0124
Sequence
Ac-D-2-Nal-D-Phe(4-CL)-3-D-Pal-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(Isopropyl)-Pro-D-Ala-NH2
Target
Antide acetate (Ac-AA10-NH2) is an LHRH antagonist and represses LH and FSH release from the pituitary gland. Antide M.W. is 1590.6 Dalton.
Description
Antide is a third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It inhibits GnRH-induced secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and gonadotropin in isolated rat pituitary cells when used at concentrations ranging from 0.001 to 1,000 nM but does not induce histamine release in isolated rat mast cells (EC50 = >300 µg/ml).  Antide (250 µg/kg, i.v.) reduces serum LH and FSH levels in orchidectomized cynomolgus monkeys.  It inhibits ovulation in rats when administered at a dose of 2 µg/animal.  Antide (10 µg/animal, s.c.) reduces the intensity and duration of catalepsy induced by haloperidol (Item No. 12014) in rats.
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg, 5mg, 25mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€30,00 – €470,00 Tax excluded
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