CGRP (Human, 8-37) (0.5 mg vial)

Product overview
Catalog Number
PPH08-0244
Sequence
Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
Target
Calcitonin Gene Related Peptide (CGRP) Antagonist
Description
Calcitonin gene-related protein (CGRP) is a neuropeptide and a product of alternative splicing of the calcitonin gene.1,2 It induces vasodilation of both arteries and veins in addition to various non-vascular biological activities. α-CGRP (8-37) is an antagonist of CGRP receptors (IC50 = 4.9 nM in SK-N-MC cells expressing the human receptor) that inhibits CGRP-induced vasodilation.2,3 In a mouse model of headache, α-CGRP (8-37) application to the dura mater reduces behavior induced by application of capsaicin and inflammatory mediators.4 α-CGRP (8-37) (human) is a peptide fragment derived from the human CGRP protein sequence.
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
Price

€280,00
  • For research use only
  • Not for use in diagnostic procedures

€280,00 Tax excluded
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