Cyclo(Arg-Gly-Asp-D-Phe-Val)
Product overview
- Catalog Number
- PPH08-0280
- Sequence
- cyclo(Arg-Gly-Asp-D-Phe-Val)
- Target
- Angiogenesis Inhibitor
- Description
- RGD peptides are fibronectin fragments that guide integrin-induced cell attachment, proliferation and migration. Cyclic RGD peptides containing D-Phe, such as cRGDfV, are selective antagonists of ανβ3 and ανβ5 integrins that inhibit the binding of these integrins to vitronectin. cRGDfV inhibits angiogenesis and vascular remodeling. cRGDfV also blocks cellular adhesion and may induce apoptosis in cells bearing surface ανβ3 integrin, although its anti-tumor effect may be primarily due to its antiangiogenic action. Fibronectin, Cyclo(-Arg-Gly-Asp-D-Phe-Val) Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Category
Product Properties
| Quantity | 25mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €729,00 |
- For research use only
- Not for use in diagnostic procedures
€729,00 Tax excluded
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