Enfuvirtide; T-20
Product overview
- Catalog Number
- PPH01-011
- Sequence
- Ac-YTSLIHSLIEESQNQQEKNEQELLE LDKWASLWNWF-NH2
- Target
- Enfuvirtide T-20
- Description
- Enfuvirtide is a biomimetic peptide inhibitor of HIV-1 fusion with CD4+ cells.1 It inhibits HIV-1 infectivity of HeLa cells stably expressing CD4 by the HXB2 strain (IC50 = 692 pM) and by clinical isolates (IC90s = 6.1-61 nM) in a single-cycle infectivity assay. It also inhibits genomic integration of HIV-1 into human intraepithelial vaginal cells and peripheral blood mononuclear cells (PBMCs; IC50s = 51.2 and 13.58 μM, respectively).2 Enfuvirtide binds to a recombinant molecular mimic of HIV-1 glycoprotein gp41 that contains three N-terminal heptad and two C-terminal heptad repeat regions (Kd = 32 nM).3 It also binds to recombinant formyl peptide receptors (FPR) expressed in rat basophilic leukemia cells (IC50 = 5 nM) and attracts and activates human peripheral blood phagocytes, but not T lymphocytes, in vitro when used at a concentration of 100 nM.4 Formulations containing enfuvirtide have been used in combination therapy for the treatment of HIV-1/AIDS.
Category
Product Properties
| Storage | Shipped at 4°C. Store at -20°C for one year. |
|---|---|
| Purity | > 95% |
| Source | Synthetic |
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