Galanin (Rat) (0.5 mg vial)

Product overview
Catalog Number
PPH08-0457
Sequence
Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-His-Gly-Leu-Thr-NH2
Target
Displays several important physiological activities.
Description
Galanin is a neuropeptide with diverse biological activities. It inhibits forskolin-induced cAMP production in cells expressing GAL1 or GAL3 receptors (EC50s = 31.6 and 91 nM, respectively) and stimulates inositol phosphate accumulation in cells expressing GAL2 receptors (EC50 = 173.3 nM). Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol (Item No. 14486; IC50s = 7.9 and 4 nM, respectively). In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and mechanical stimulation in a rat model of carrageenin-induced inflammation when administered at a dose of 2 nmol injected into the nucleus accumbens. Galanin (5 μg, i.c.v.) also inhibits acetylcholine (Item No. 23829) release induced by scopolamine in the ventral hippocampus of freely moving rats.
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
Price

€430,00
  • For research use only
  • Not for use in diagnostic procedures

€430,00 Tax excluded
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