GsMTx-4 (0.1mg vial)
Product overview
- Catalog Number
- PPH08-0477
- Sequence
- H-Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2
- Target
- Inhibitor for Cation-Selective Stretch-Activated Channels /Atrial Fibrillation Inhibiting Peptide, A synthetic tarantula spider toxin
- Description
- GsMTX4 is a 34 amino acid peptidyl toxin isolated from the Grammostola rosea (Chilean rose) tarantula venom and belongs to the huwentoxin-1 family. GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor. Mechanosensitive and stretch-activated ion channel inhibitor. GsMTx-4 interacts to the group of mechanosensitive ion channels (MSCs) which are ubiquitous from unicellular to multicellular organisms and participate in numerous physiological processes including touch and pain sensation, salt and fluid balance, blood pressure control, cell volume regulation, and turgor control [Physiol. Rev., 81, 685 (2001)]. Analysis of the functions mediated by these channels can be performed by utilizing a specific blocker with high selectivity to the particular channels. In the research of stretch-activated ion channels (SACs), one of MSCs, cationic metal, Gd3+, and cationic compounds including amiloride, and cationic antibiotics have been used as blockers, but were reported to be non-selective (lack of specificity). In 2000, Professor F. Sachs of State University of New York at Buffalo discovered a peptidic toxin named GsMTx-4 in the venom of the tarantula Grammostola spatulata and repoted it to possess a specific blocking activity for stretch-activated currents.
Category
Product Properties
| Quantity | 1mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €259,00 |
- For research use only
- Not for use in diagnostic procedures
€259,00 Tax excluded
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