HIV-1 TAT Clade-C Recombinant
Product overview
- Catalog Number
- PPH08-0595
- Sequence
- -
- Target
- Viral Antigens; HIV. Reacts with anti-Tat polyclonal antibodies from human, monkey, rabbit and mouse serum. Recognized by anti-Tat (HIV-1) polyclonal antibody.
- Description
- Immunoreactive with all sera of HIV-1 infected individuals. HIV-1 TAT Recombinant- produced in E.coli is a single, non-glycosylated, polypeptide chain containing 100 amino acids encoded by two exons and having chain having a molecular mass of 21 kDa.; 0.1% glycerol. Immunoreactive with all sera of HIV-1 infected i. HIV-1 regulatory Trans-Acting Transcription factor (TAT) plays an essential role in viral replication and infectivity. In addition, during acute infection, TAT is released extracellularly by infected cells and is taken up by neighboring cells where it transactivates viral replication and increases virus infectivity.HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain(CTD) of RNA polymerase II.Tat can also disturb cellular metabolism by inhibiting proliferation of antigen-specific T lymphocytes and by inducing cellular apoptosis.
Category
Product Properties
| Quantity | 2µg, 10µg, 100µg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
- For research use only
- Not for use in diagnostic procedures
€30,00 – €1.180,00 Tax excluded
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