INSL5
Product overview
- Catalog Number
- PPH08-0648
- Sequence
- Insulin-like peptide INSL5 B chain Insulin-like peptide INSL5 A chain
- Target
- Treating human conditions such as constipation, anorexia, and obesity
- Description
- Insulin-like peptide INSL5 is a protein that in humans is encoded by the INSL5 gene. The receptor for insulin-like peptide 5 (INSL5), RXFP4, is a potential pharma target for treating human conditions such as constipation, anorexia, and obesity. However, since INSL5 has a complex structure of two chains and three disulfide bonds, its synthesis has proven to be extremely difficult via either chemical or recombinant approaches. Previous studies led to the engineering of a high yielding simplified INSL5 analog, named analog 13 (A13), which retains native INSL5-like activity. The focus of this study is to further simplify the structure of A13 by truncating the N-terminal residues of the B-chain. We have found that the first six residues at the N-terminus of A13 are not important for RXFP4 binding and cAMP potency. The most minimized active structure of INSL5 identified in this study is A13: B7–24 which will be an important research tool to study the physiological role of RXFP4 and a template for further modification to improve its pharmacokinetic properties.
Category
Product Properties
| Quantity | 25µg, 50µg, 100µg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
- For research use only
- Not for use in diagnostic procedures
€205,00 – €730,00 Tax excluded
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