Insulin-like Growth Factor-1 Receptor (Human) (recombinant)

Product overview
Catalog Number
PPH08-0628
Sequence
YNITDPEELE TEYPFFESRV DNKERTVISN LRPFTLYRID IHSCNHEAEK LGCSASNFVF ARTMPAEGAD DIPGPVTWEP RPENSIFLKW PEPENPNGLI LMYEIKYGSV EDQRECVSRQ EYRKYGGAKL NRLNPGNYTA RIQATSLSGN GSWTDPVFFY VQAKTGYE
Target
Potential biomarker of improved clinical outcome in HR+ve breast cancer patients treated with exemestane.
Description
The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth promoting effect of this receptor. Mice carrying only one functional copy of igf1r are normal, but exhibit a ~15% decrease in body mass. CD221; IGF1-R; IGFIR; JTK13.
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

2µg, 5µg, 10µg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€155,00 – €470,00 Tax excluded
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