Margatoxin (0.1mg vial)

Product overview
Catalog Number
PPH08-0707
Sequence
Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His
Target
Volgate-Dependent K+ Channel Blocker (Specific for Kv13 Channel), A synthetic scorpion toxin
Description
Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 µM concentration. Margatoxin is known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50 around 1 nM). Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM.(Scorpion, Centruroides margaritatus) (Disulfide bonds between Cys7-Cys29,Cys13-Cys34, and Cys17-Cys36) (M.W. 4178.9) C178H286N52O50S7 [145808-47-5] Volgate-Dependent K+ Channel Blocker (Specific for Kv1.3 Channel)
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
Price

€269,00
  • For research use only
  • Not for use in diagnostic procedures

€269,00 Tax excluded
Contact us to request price here
Register to buy peptides
Contact us