[N-Me-Asp1]-Angiotensin II

Product overview
Catalog Number
PPH08-0804
Sequence
N-Me-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Target
Vasoconstrictive Peptide / Angiotensin Peptide
Description
Angiotensin II acts on the central nervous system to increase vasopressin production, and also acts on venous and arterial smooth muscle to cause vasoconstriction. Angiotensin II also increases aldosterone secretion; it therefore acts as an endocrine, autocrine/paracrine, and intracrine hormone. ACE is a target of ACE inhibitor drugs, which decrease the rate of angiotensin II production. Angiotensin II increases blood pressure by stimulating the Gq protein in vascular smooth muscle cells (which in turn activates an IP3-dependent mechanism leading to a rise in intracellular calcium levels and ultimately causing contraction). In addition, angiotensin II acts at the Na+/H+ exchanger in the proximal tubules of the kidney to stimulate Na reabsorption and H+ excretion which is coupled to bicarbonate reabsorption. This ultimately results in an increase in blood volume, pressure, and pH.[16] Hence, ACE inhibitors are major anti-hypertensive drugs. (M.W. 1060.23) C51H73N13O12 Vasoconstrictive Peptide / Angiotensin Peptide
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg, 5mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€39,00 – €226,00 Tax excluded
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