Proinsullin (Human)

Product overview
Catalog Number
PPH08-0926
Sequence
FVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQ
Target
Better predictor of future type 2 diabetes than fasting insulin levels in obese children.
Description
E. coli derived Human Proinsulin (Phe25 -Asn110) is made using the BioPure™ process, ensuring unequaled purity and lack of process or product-related contaminants. Proinsulin is synthesized as a single chain, 110 amino acid (aa) preproprecursor that contains a 24 aa signal sequence and an 86 aa proinsulin propeptide (Bell et al, Nature). Following removal of the signal peptide, the proinsulin peptide undergoes further proteolysis to generate mature insulin, a 51 aa disulfide-linked dimer that consists of a 30 aa B chain (aa 25 – 54) bound to a 21 aa A chain (aa 90 – 110). The 34 aa intervening peptide (aa 55 – 89) that connects the B and A chains is termed the C-peptide (Forst et al. Exp. Diabetes Res). Human proinsulin shares 84% and 80% aa sequence identity with rat and bovine proinsulin, respectively.
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

5µg, 10µg, 500µg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€330,00 – €1.980,00 Tax excluded
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