[Pyr1]-Apelin-13 (Human, Bovine) (0.5 mg vial)

Product overview
Catalog Number
PPH08-0859
Sequence
Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Target
Ligand for APJ Receptor
Description
[125I]-(Pyr1)Apelin-13 binds with high affinity and selectivity to human cardiac tissue. Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids. Upon signal peptide cleavage, the proprotein of 55 amino acids may generate several active fragments: Apelin-36 (36 aa corresponding to the sequence 42-77), Apelin-17 (17 aa corresponding to the sequence 61-77) and Apelin-13 (13 aa corresponding to the sequence 65-77). Apelin-13 may undergo a pyroglutamylation at its N-terminal glutamine residue. Apelin has been described as endogenous ligand for human APJ. Its pyroglutaminated C-terminal peptide [Pyr1]-Apelin-13 ( [pGlu]-Apelin-13 ) was more potent than Apelin-36 in competitive inhibition assays. This pyroglutaminated peptide shows in vivo very high vascular effects. [Pyr1]-Apelin-13 shows a clear vasodilation effect in man. (M.W. 1533.8) C69H108N22O16S [217082-60-5] Ligand for APJ Receptor
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
Price

€71,00
  • For research use only
  • Not for use in diagnostic procedures

€71,00 Tax excluded
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