Rapamycin

Product overview
Catalog Number
PPH07-287
Sequence
23,27-Epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclohentriacontine
Target
mTOR Inhibitor, Rapamycin is a clinically useful immunosuppressant that inhibits the response to interleukin-2 blocking activation of T- and B-cells and induces autophagy. Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that binds
Description
Rapamycin is a bacterial macrolide with antifungal and immunosuppressant activities. Sirolimus, Rapamune, NSC 226080, Antibiotic AY-22989, WY-090217, RAPA, SILA 9268A, CCRIS 9024; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine. Rapamycin is an inhibitor of the Ser/Thr protein kinase mTOR (mammalian target of rapamycin), which regulates cell growth and metabolism in response to environmental cues. Rapamycin is also an inducer of autophagy, as inhibition of mTOR mimics cellular starvation by blocking signals required for cell growth and proliferation. Furthermore, mTOR is a downstream target of PI3K, an important actor in TLR signaling. Indeed, Rapamycin can block TLR2- and TLR4-mediated expression of TNF-α and IL-6 in neutrophils stimulated with Pam3CSK4 or LPS. 53123-88-9. 914.17
Category
Enzyme Inhibitors and Substrates, Catalog peptides
Product Properties
Quantity

100mg, 1000mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€50,00 – €330,00 Tax excluded
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