Rfamide-Related Peptide-1 (Human) (0.1mg vial)
Product overview
- Catalog Number
- PPH08-0927
- Sequence
- Ser-Leu-Asn-Phe-Glu-Glu-Leu-Lys-Asp-Trp-Gly-Pro-Lys-Asn-Val-Ile-Lys-Met-Ser-Thr-Pro-Ala-Val-Asn-Lys-Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2
- Target
- Prolactin Secreting Peptide
- Description
- RFRP-1 (Human) | Prepro (56-92) Amide. Human RFRP-1 was first predicted to be a 12 amino acid residue peptide. Subsequent synthesis and biochemical studies found it to be a ligand for the orphan receptor, OT7T022 (also called FF1) [Nat. Cell Biol., 2, 703 (2000) ]. Later, the endogenous form of human RFRP-1 was determined to be composed of 37 amino acid residues including the above 12-residue peptide at its C-terminus [Biochim. Biophys. Acta., 1540, 221 (2001) ]. The same peptide was isolated by another group who named it NPSF(1-37) [J. Biol. Chem., 276, 36961 (2001) ]. Human RFRP-1 inhibits forskolin-stimulated cAMP production in CHO cells expressing OT7T022 (ED50=21 nM). The potency is slightly less than that of the 12-residue peptide (ED50=4.9 nM), however, this result suggests that the C-terminal portion of RFRP-1 is responsible for the recognition of OT7T022. Immunoreactive RFRP-1 was observed in the central nervous system (CNS), with the highest amount detected in the hypothalamus. (M.W. 4256.9) C195H304N52O51S2. Synthetic Product. Prolactin Secreting Peptide
Category
Product Properties
| Quantity | 1mg |
|---|---|
| Storage | Shipped at 4°C. Store at -20°C for one year. |
| Purity | > 95% |
| Source | Synthetic |
| Forma appearance | Lyophilized powder |
| Price | €141,00 |
- For research use only
- Not for use in diagnostic procedures
€141,00 Tax excluded
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