RhTx

Product overview
Catalog Number
PPH08-0928
Sequence
H-Leu-Asn-Asn-Pro-Cys-Asn-Gly-Val-Thr-Cys-Pro-Ser-Gly-Tyr-Arg-Cys-Ser-Ile-Val-Asp-Lys-Gln-Cys-Ile-Lys-Lys-Glu-OH
Target
Rh-Tx is a 27 amino acid peptide toxin from the venom of the Chinese red-headed centipede and a potent activator of TRPV1 capsaicin receptor, inducing intense pain.
Description
Rh-Tx is a 27 amino acid peptide toxin from the venom of the Chinese red-headed centipede and a potent activator of TRPV1 capsaicin receptor, inducing intense pain. RhTx binds to the outer pore region of the temperature regulated TRPV1 ion channel, preferably in activated state, causing a downwards shift in the activation threshold temperature, which leads to the immediate onset of heat pain. RhTx is a small peptide toxin, with a compact 3D-structure. The gene encoding for RhTx translates into a 69 amino acid peptide that shows no homology to any known animal toxin. This peptide, after post- translational modifications, yields a mature toxin of 27 amino acids. RhTx has two pairs of disulfide bonds. While the N-terminus of the peptide contains no charged amino acids, the C-terminus of the peptide is rich in charged amino acids. In the folded peptide, these charged amino acids are all located on the same side of the peptide, making RhTx a polar molecule. C123H201N37O40S4. Disulfide Bonds: Cys1-Cys3, Cys2-Cys4. 2966.45
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg, 5mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€622,00 – €2.548,00 Tax excluded
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