Soybean BBI

Product overview
Catalog Number
PPH07-315
Sequence
DDESSKPCCDQCACTKSNPPQCRCSDMRLNSCHSACK SCICALSYPAQCFCVDITDFCYEPCKPSEDDKEN
Target
Bowman-Birk Soybean Inhibitor
Description
The Bowman-Birk inhibitor (BBI), a soybean-derived protease inhibitor, is known to have anti-inflammatory effect in both in vitro and in vivo systems. Macrophages play a key role in inflammation and immune activation, which is implicated in HIV disease progression. Here, we investigated the effect of BBI on HIV infection of peripheral blood monocyte-derived macrophages. We demonstrated that BBI could potently inhibit HIV replication in macrophages without cytotoxicity. Investigation of the mechanism(s) of BBI action on HIV showed that BBI induced the expression of IFN-β and multiple IFN stimulated genes (ISGs), including Myxovirus resistance protein 2 (Mx2), 2′,5′-oligoadenylate synthetase (OAS-1), Virus inhibitory protein (viperin), ISG15 and ISG56.
Category
Enzyme Inhibitors and Substrates, Catalog peptides
Product Properties
Quantity

50µg, 100µg, 500µg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€330,00 – €1.980,00 Tax excluded
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