TAPI-1

Product overview
Catalog Number
PPH07-317
Sequence
HONHCOCH2CH(CH2CH(CH3)2)CO-Nal-Ala-NHCH2CH2NH2
Target
Inhibitor for Collagenase, MMP, and α-Tumor Necrosis Factor
Description
TNF-α converting enzyme (TACE, also known as ADAM17) is a zinc metalloprotease that cleaves the membrane-bound precursor of TNF-α to give the mature soluble form of TNF-α.1,2 It also mediates the proteolytic release of several other cell-surface proteins, including TNF-α receptors (TNFRs). TAPI-1, known in the earlier literature as just TAPI, is an inhibitor of TACE that inhibits the cleavage of TNF-α, TNFRI (p60), and TNFRII (p80) with IC50 values ranging from 5-100 µM.1,3,4 It also blocks the shedding of other TACE-dependent proteins, including IL-6R and Klotho, and may inhibit metalloproteases other than TACE.2,5,6 TAPI-1 differs from TAPI-0 (Item No. 14694), structurally, by the presence of an aminoethyl addition at the alanyl group, and is generally more stable in tissue culture and in vivo. N-®-(2-(Hydroxyaminocarbonyl)Methyl)-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine 2-Aminoethyl Amide (M.W. 499.62) C26H37N5O5 Inhibitor for Collagenase, MMP, and alpha-Tumor Necrosis Factor
Category
Enzyme Inhibitors and Substrates, Catalog peptides
Product Properties
Quantity

1mg, 5mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€114,00 – €490,00 Tax excluded
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