TAPI-2

Product overview
Catalog Number
PPH07-318
Sequence
HONHCOCH2CH(CH2CH(CH3)2)CO-t-Butyl-Gly-Ala-NHCH2CH2NH2
Target
Inhibitor for Metalloproteases
Description
The extracellular domains of many different types of transmembrane proteins, including growth factors, growth factor receptors and cell adhesion molecules, are proteolytically released (shed) in response to environmental cues. TNF protease inhibitor 2 (TAPI-2) is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE), other ADAMs (a disintegrin and metalloproteinases), and other matrix metalloproteinases. It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit, with an IC50 value of 10 µM.1 TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 µM, respectively.2 In T4-2 breast cancer cells, 20 µM TAPI-2 prevented mobilization of the growth factors TGF-α and amphiregulin leading to reversion of the malignant cellular phenotype. N-®-(2-(Hydroxyaminocarbonyl) Methyl)-4-Methylpentanoyl-L-t-Butyl-Gly-L-Alanine 2-Aminoethyl Amide (M.W. 415.54) C19H37N5O5 Inhibitor for Metalloproteases.
Category
Enzyme Inhibitors and Substrates, Catalog peptides
Product Properties
Quantity

1mg, 5mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€114,00 – €510,00 Tax excluded
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