[Trp3, Arg5]-Ghrelin (1-5)

Product overview
Catalog Number
PPH08-0980
Sequence
H-Gly-Ser-Trp-Phe-Arg-OH
Target
Growth-Hormone Secretagogue (GHS) Receptor Agonist / Stimulates Food-Intake
Description
[Trp3, Arg5]-ghrelin(1-5) (GSWFR), a novel pentapeptide composed of all L-amino acids, had affinity for the GHS receptor (IC50 = 10 microM). GSWFR stimulated GH secretion after intravenous or oral administration. Centrally administered GSWFR increased food intake in non-fasted mice. The orexigenic action of GSWFR was inhibited by a GHS receptor antagonist, [D-Lys3]-GH-releasing peptide-6, suggesting that GSWFR stimulated food intake through the GHS receptor. The orexigenic action of GSWFR was also inhibited by a neuropeptide Y (NPY) Y1 receptor antagonist, BIBO3304. These results suggest that the GSWFR-induced feeding is mediated by the NPY Y1 receptor. GSWFR H-Gly-Ser-Trp-Phe-Arg-OH (M.W. 651.73) C31H41N9O7 Growth-Hormone Secretagogue (GHS) Receptor Agonist / Stimulates Food-Intake
Category
Catalog peptides, Biologically Active Peptides
Product Properties
Quantity

1mg, 5mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€69,00 – €333,00 Tax excluded
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