Ubenimex (Bestatin) HCl Salt

Product overview
Catalog Number
PPH07-325
Sequence
[(2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanoyl]-L-Leucine
Target
An Inhibitor of Aminopeptidases, Leucine Aminopeptidase 3 (LAP3), and a Potent, Irreversible Inhibitor of Leukotriene A4 (LTA4) Hydrolase. Has antibacterial properties against P. gingivalis and F. nucleatum.
Description
Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli. It inhibits aminopeptidase B (IC50 = 0.05 µg/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 µg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM). It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin. Bestatin inhibits the production of LTB4 (Item No. 20110) in erythrocytes when used at a concentration of 70 µM. It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells.4 Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.Hydrochloride. CAS 65391-42-6 Molecular Weight: 308.38 x 36.46
Category
Enzyme Inhibitors and Substrates, Catalog peptides
Product Properties
Quantity

1mg, 5mg, 25mg, 100mg
Storage

Shipped at 4°C. Store at -20°C for one year.
Purity

> 95%
Source

Synthetic
Forma appearance

Lyophilized powder
  • For research use only
  • Not for use in diagnostic procedures

€11,00 – €682,00 Tax excluded
Contact us to request price here
Register to buy peptides
Contact us