The disease, caused by the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), is called as Coronavirus disease 2019 (COVID-19).
Coronavirus disease 2019 (COVID-19)
The COVID-19 has now become a global pandemic and it continues to spread rapidly worldwide, severely threatening lives and economic stability. Making the problem worse, there is no specific antiviral drug that can be used to treat COVID-19 to date. SARS-CoV-2 initiates its entry into human cells by binding to angiotensin-converting enzyme 2 (hACE2) via the receptor binding domain (RBD) of its spike protein. Therefore, molecules that can block SARS-CoV-2 from binding to hACE2 may potentially prevent the virus from entering human cells and serve as an effective diagnostic approach. Based on this idea, we designed a series of peptides that can strongly bind to SARS-CoV-2 RBD. We also designed a series of peptides that specifically can be recognize but human sera.
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